The evolution of evolutionary molecular medicine

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This article introduces a special issue of the Journal of Molecular Medicine on Evolutionary Molecular Medicine. The first paragraphs are below.

New technologies have always been the driving forces for major developments in science. Medicine is no exception. New sequencing technologies have enabled us to begin understanding the genomic and molecular origins of life and the reasons for disease; they are also transforming evolutionary biology into a new, precise, molecular science that has enormous promise for advancing medicine and public health [1]. This issue of the Journal of Molecular Medicine has invited papers to discuss this exciting development.

Evolution comes to medicine, genomics comes to evolution Medical doctors are trained to taking a detailed history from their patients, their personal history, a family history (and tree if indicated), and the time course symptoms and laboratory tests. Now we look back into the history of mankind and to the origins of life 3.5 billion years ago to understand why we get sick. The history-taking process has thus been extended from the individual to his phylogenetic ancestors. The transformation of medicine by genomics will eventually be recognized among the most significant in a long history of innovations. The beginnings of modern medicine were made…(see article for more)

Posted in evolutionary medicine

 

The evolution of evolutionary molecular medicine

AppId is over the quota AppId is over the quota

This article introduces a special issue of the Journal of Molecular Medicine on Evolutionary Molecular Medicine. The first paragraphs are below.

New technologies have always been the driving forces for major developments in science. Medicine is no exception. New sequencing technologies have enabled us to begin understanding the genomic and molecular origins of life and the reasons for disease; they are also transforming evolutionary biology into a new, precise, molecular science that has enormous promise for advancing medicine and public health [1]. This issue of the Journal of Molecular Medicine has invited papers to discuss this exciting development.

Evolution comes to medicine, genomics comes to evolution Medical doctors are trained to taking a detailed history from their patients, their personal history, a family history (and tree if indicated), and the time course symptoms and laboratory tests. Now we look back into the history of mankind and to the origins of life 3.5 billion years ago to understand why we get sick. The history-taking process has thus been extended from the individual to his phylogenetic ancestors. The transformation of medicine by genomics will eventually be recognized among the most significant in a long history of innovations. The beginnings of modern medicine were made…(see article for more)

Posted in evolutionary medicine

 

Evolutionary Medicine Conference Tue May 8 at Stanford

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New Opportunities at the Intersection of Evolution and Medicine
A gathering of scientists and entrepreneurs

8:00 – 8:30 Coffee and Registration

8:30 – 8:50 Welcome
Charles Cho, MD, Associate Professor Neurology and Neurological Sciences, Stanford University
Introductory Remarks by Joon Yun, MD, Palo Alto Investors and David Sloan Wilson, Binghamton University

8:50 – 9:30 Keynote Address
Evolutionary Medicine: Envisioning the Opportunities
Keynote Address by Randolph M. Nesse, MD, University of Michigan

9:30 – 10:10 Session One: Infectious Disease
Evolution Proof Pharmaceuticals?
Andrew F. Read, Penn State

Panel discussion to follow moderated by David Sloan Wilson, Binghamton University
Panelists include James Holland Jones, Stanford University, and Nina Kjellson, Interwest

10:10 – 10:40 Break

10:40 – 11:45 Session Two: Cancer
Why Evolution Holds the Key to Curing and Preventing Cancer
Carlo C Maley, University of California at San Francisco

The Evolution and Ecology of Metastasis: Can we Control Cancer by Targeting Dispersal Evolution?
Athena Aktipis, Arizona State University, UCSF Center for Evolution and Cancer

Panel discussion to follow moderated by Randolph M. Nesse
Panelists include Daniel S. Fisher, Stanford University

11:45 – 12:30 Session Three: Application of a Specific Theory
Using Drugs to Induce Adaptation
Introduced and moderated by Joon Yun, MD, Palo Alto Investors

Panelists include Ray Onders, Synapse; Lorenzo DiCarlo, Proteus Biomedical; Richard A. Bond, University of Houston; Kari Nadeau, Stanford University

12:30 – 1:30 Lunch

1:30 – 2:15 Session Four: Behavior
Improving Health by Changing Behavior: Evolution Science Shows How
Steven C. Hayes, University of Nevada

Panel discussion to follow moderated by David Sloan Wilson
Panelists include William H. Durham, Stanford University, and Camille Samuels, Versant Ventures

2:15 – 3:00 Session Five: Genetics and Mental Disorders
Where Darwin meets Freud: Psychiatric Conditions and Therapies at the Dawn of Evolutionary Genomics.
Bernie Crespi, Simon Fraser University

Panel discussion to follow moderated by Randolph M. Nesse
Panelists include Charles Cho, MD, Associate Professor Neurology and Neurological Sciences, Stanford University

3:00 – 3:30 Break

3:30 – 4:15 Session Six: Diet
What did Humans Evolve to Eat? Evolutionary Perspectives on Human Nutritional Health
William R. Leonard, Northwestern University

Panel discussion to follow moderated by David Sloan Wilson
Panelists include Dr. John Morton, Stanford University, and Scott Wolf, Aerin Medical

4:15 – 5:00 Session Seven: Aging
Can we Have it All? What Evolutionary Biology Says about Medically Slowing Aging.
Steven Austad, University of Texas Health Science Center San Antonio

Panel discussion to follow moderated by Joon Yun, MD, Palo Alto Investors
Panelists include Jim Glasheen, Technology Partner

5:00 – 5:15 Wrap

5:30 – 6:30 Cocktails & Networking

Full information available here

 

Evolutionary Medicine Conference Tue May 8 at Stanford

AppId is over the quota AppId is over the quota

New Opportunities at the Intersection of Evolution and Medicine
A gathering of scientists and entrepreneurs

8:00 – 8:30 Coffee and Registration

8:30 – 8:50 Welcome
Charles Cho, MD, Associate Professor Neurology and Neurological Sciences, Stanford University
Introductory Remarks by Joon Yun, MD, Palo Alto Investors and David Sloan Wilson, Binghamton University

8:50 – 9:30 Keynote Address
Evolutionary Medicine: Envisioning the Opportunities
Keynote Address by Randolph M. Nesse, MD, University of Michigan

9:30 – 10:10 Session One: Infectious Disease
Evolution Proof Pharmaceuticals?
Andrew F. Read, Penn State

Panel discussion to follow moderated by David Sloan Wilson, Binghamton University
Panelists include James Holland Jones, Stanford University, and Nina Kjellson, Interwest

10:10 – 10:40 Break

10:40 – 11:45 Session Two: Cancer
Why Evolution Holds the Key to Curing and Preventing Cancer
Carlo C Maley, University of California at San Francisco

The Evolution and Ecology of Metastasis: Can we Control Cancer by Targeting Dispersal Evolution?
Athena Aktipis, Arizona State University, UCSF Center for Evolution and Cancer

Panel discussion to follow moderated by Randolph M. Nesse
Panelists include Daniel S. Fisher, Stanford University

11:45 – 12:30 Session Three: Application of a Specific Theory
Using Drugs to Induce Adaptation
Introduced and moderated by Joon Yun, MD, Palo Alto Investors

Panelists include Ray Onders, Synapse; Lorenzo DiCarlo, Proteus Biomedical; Richard A. Bond, University of Houston; Kari Nadeau, Stanford University

12:30 – 1:30 Lunch

1:30 – 2:15 Session Four: Behavior
Improving Health by Changing Behavior: Evolution Science Shows How
Steven C. Hayes, University of Nevada

Panel discussion to follow moderated by David Sloan Wilson
Panelists include William H. Durham, Stanford University, and Camille Samuels, Versant Ventures

2:15 – 3:00 Session Five: Genetics and Mental Disorders
Where Darwin meets Freud: Psychiatric Conditions and Therapies at the Dawn of Evolutionary Genomics.
Bernie Crespi, Simon Fraser University

Panel discussion to follow moderated by Randolph M. Nesse
Panelists include Charles Cho, MD, Associate Professor Neurology and Neurological Sciences, Stanford University

3:00 – 3:30 Break

3:30 – 4:15 Session Six: Diet
What did Humans Evolve to Eat? Evolutionary Perspectives on Human Nutritional Health
William R. Leonard, Northwestern University

Panel discussion to follow moderated by David Sloan Wilson
Panelists include Dr. John Morton, Stanford University, and Scott Wolf, Aerin Medical

4:15 – 5:00 Session Seven: Aging
Can we Have it All? What Evolutionary Biology Says about Medically Slowing Aging.
Steven Austad, University of Texas Health Science Center San Antonio

Panel discussion to follow moderated by Joon Yun, MD, Palo Alto Investors
Panelists include Jim Glasheen, Technology Partner

5:00 – 5:15 Wrap

5:30 – 6:30 Cocktails & Networking

Full information available here

 

Evolutionary Medicine Conference Tue May 8 at Stanford

AppId is over the quota AppId is over the quota

New Opportunities at the Intersection of Evolution and Medicine
A gathering of scientists and entrepreneurs

8:00 – 8:30 Coffee and Registration

8:30 – 8:50 Welcome
Charles Cho, MD, Associate Professor Neurology and Neurological Sciences, Stanford University
Introductory Remarks by Joon Yun, MD, Palo Alto Investors and David Sloan Wilson, Binghamton University

8:50 – 9:30 Keynote Address
Evolutionary Medicine: Envisioning the Opportunities
Keynote Address by Randolph M. Nesse, MD, University of Michigan

9:30 – 10:10 Session One: Infectious Disease
Evolution Proof Pharmaceuticals?
Andrew F. Read, Penn State

Panel discussion to follow moderated by David Sloan Wilson, Binghamton University
Panelists include James Holland Jones, Stanford University, and Nina Kjellson, Interwest

10:10 – 10:40 Break

10:40 – 11:45 Session Two: Cancer
Why Evolution Holds the Key to Curing and Preventing Cancer
Carlo C Maley, University of California at San Francisco

The Evolution and Ecology of Metastasis: Can we Control Cancer by Targeting Dispersal Evolution?
Athena Aktipis, Arizona State University, UCSF Center for Evolution and Cancer

Panel discussion to follow moderated by Randolph M. Nesse
Panelists include Daniel S. Fisher, Stanford University

11:45 – 12:30 Session Three: Application of a Specific Theory
Using Drugs to Induce Adaptation
Introduced and moderated by Joon Yun, MD, Palo Alto Investors

Panelists include Ray Onders, Synapse; Lorenzo DiCarlo, Proteus Biomedical; Richard A. Bond, University of Houston; Kari Nadeau, Stanford University

12:30 – 1:30 Lunch

1:30 – 2:15 Session Four: Behavior
Improving Health by Changing Behavior: Evolution Science Shows How
Steven C. Hayes, University of Nevada

Panel discussion to follow moderated by David Sloan Wilson
Panelists include William H. Durham, Stanford University, and Camille Samuels, Versant Ventures

2:15 – 3:00 Session Five: Genetics and Mental Disorders
Where Darwin meets Freud: Psychiatric Conditions and Therapies at the Dawn of Evolutionary Genomics.
Bernie Crespi, Simon Fraser University

Panel discussion to follow moderated by Randolph M. Nesse
Panelists include Charles Cho, MD, Associate Professor Neurology and Neurological Sciences, Stanford University

3:00 – 3:30 Break

3:30 – 4:15 Session Six: Diet
What did Humans Evolve to Eat? Evolutionary Perspectives on Human Nutritional Health
William R. Leonard, Northwestern University

Panel discussion to follow moderated by David Sloan Wilson
Panelists include Dr. John Morton, Stanford University, and Scott Wolf, Aerin Medical

4:15 – 5:00 Session Seven: Aging
Can we Have it All? What Evolutionary Biology Says about Medically Slowing Aging.
Steven Austad, University of Texas Health Science Center San Antonio

Panel discussion to follow moderated by Joon Yun, MD, Palo Alto Investors
Panelists include Jim Glasheen, Technology Partner

5:00 – 5:15 Wrap

5:30 – 6:30 Cocktails & Networking

Full information available here

 

Evolutionary Molecular Medicine

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Abstract

Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

Posted in evolutionary medicine

 

Evolutionary Molecular Medicine

AppId is over the quota AppId is over the quota

Abstract

Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

Posted in evolutionary medicine

 

Evolutionary Molecular Medicine

AppId is over the quota AppId is over the quota

Abstract

Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

Posted in evolutionary medicine